| Sep 19, 1980 Fri | Preseason | Boston | Philadelphia | Add Fight |
| Sep 20, 1980 Sat | Preseason | Boston | NY Islanders | Milbury-Howatt Bourque-Howatt |
| Sep 22, 1980 Mon | Preseason | Philadelphia | Boston | Add Fight |
| Sep 23, 1980 Tue | Preseason | NY Rangers | Boston | Kotsopoulos-Wensink Davidson-Wensink |
| Sep 25, 1980 Thu | Preseason | Buffalo | Boston | Playfair-Secord Playfair-Secord |
| Sep 26, 1980 Fri | Preseason | Boston | Hartford | Add Fight |
| Sep 27, 1980 Sat | Preseason | Boston | Hartford | MacTavish-Miller |
| Sep 30, 1980 Tue | Preseason | Boston | Montreal | Add Fight |
| Oct 3, 1980 Fri | Preseason | Boston | Montreal | Add Fight |
| Oct 4, 1980 Sat | Preseason | Boston | Buffalo | Add Fight |
| Oct 5, 1980 Sun | Preseason | Boston | NY Rangers | Add Fight |
| Oct 9, 1980 Thu | | NY Rangers | Boston | (Rough) Connor-Jonathan Scrum at 39:18 Marois-Middleton Unknown-O'Reilly |
| Oct 11, 1980 Sat | | Boston | NY Islanders | Secord-Nystrom |
| Oct 12, 1980 Sun | | Montreal | Boston | Add Fight |
| Oct 15, 1980 Wed | | Boston | Minnesota | Miller-Zanussi |
| Oct 16, 1980 Thu | | Boston | Calgary | Add Fight |
| Oct 18, 1980 Sat | | Boston | St. Louis | Add Fight |
| Oct 22, 1980 Wed | | Boston | Los Angeles | Add Fight |
| Oct 24, 1980 Fri | | Boston | Vancouver | O'Reilly-Fraser |
| Oct 26, 1980 Sun | | Boston | Winnipeg | O'Reilly-Campbell |
| Oct 30, 1980 Thu | | Calgary | Boston | Smith-Jonathan (3.5) |
| Nov 2, 1980 Sun | | Boston | Philadelphia | Add Fight |
| Nov 6, 1980 Thu | | NY Islanders | Boston | Tambellini-Milbury Gillies-Jonathan (6.7) |
| Nov 9, 1980 Sun | | Pittsburgh | Boston | Add Fight |
| Nov 11, 1980 Tue | | Boston | Detroit | Bourque-Polonich (5.5) Kasper-Woods |
| Nov 13, 1980 Thu | | Winnipeg | Boston | Add Fight |
| Nov 15, 1980 Sat | | Boston | Pittsburgh | O'Reilly-Wolf Cashman-Hughes (6) |
| Nov 16, 1980 Sun | | Philadelphia | Boston | Morrison-Melnyk (7.3) Wilson-Park (3) |
| Nov 20, 1980 Thu | | Colorado | Boston | Add Fight |
| Nov 22, 1980 Sat | | Boston | Washington | O'Reilly-Hangsleben |
| Nov 23, 1980 Sun | | Toronto | Boston | Add Fight |
| Nov 26, 1980 Wed | | Boston | NY Rangers | Melnyk-Laidlaw |
| Nov 27, 1980 Thu | | Pittsburgh | Boston | (Cheap) unknown-Melnyk |
| Nov 29, 1980 Sat | | Edmonton | Boston | Brackenbury-Melnyk (5) |
| Dec 2, 1980 Tue | | Detroit | Boston | Polonich-Secord (1) Larson-Jonathan (2) Hicks-Morrison Larson-Foster |
| Dec 6, 1980 Sat | | Boston | Montreal | Secord-Nilan (6.3) |
| Dec 7, 1980 Sun | | Washington | Boston | Hangsleben-Jonathan (6) Walker-Melnyk Kelly-Secord |
| Dec 10, 1980 Wed | | Boston | Quebec | (Rough) Milbury-Ftorek |
| Dec 11, 1980 Thu | | Quebec | Boston | unknown-Cashman |
| Dec 13, 1980 Sat | | Vancouver | Boston | Williams-O'Reilly (3) |
| Dec 14, 1980 Sun | | Los Angeles | Boston | Keans-O'Reilly (7) |
| Dec 17, 1980 Wed | | Boston | Hartford | Milbury-Rowe |
| Dec 18, 1980 Thu | | St. Louis | Boston | Add Fight |
| Dec 20, 1980 Sat | | Hartford | Boston | Add Fight |
| Dec 27, 1980 Sat | | Boston | Toronto | Jonathan-Vaive MacTavish-Maloney |
| Dec 28, 1980 Sun | | Boston | Buffalo | Add Fight |
| Dec 31, 1980 Wed | | Boston | Chicago | O'Reilly-Fox |
| Jan 2, 1981 Fri | | Boston | Edmonton | Crowder-Coffey O'Reilly-Driscoll |
| Jan 3, 1981 Sat | | Boston | Colorado | Milbury-Cooper (4) O'Reilly-Delorme Kasper-Hughes Brawl at 52:44 McCrimmon-Gillis Jonathan-Hughes Ratelle-Kitchen Bourque-DeBlois O'Reilly-McKechnie Craig-Robert (3) Bench-Clearing Brawl at 58:54 (8) Park-Delorme (1) McCrimmon-Robert Craig-Smith (4) |
| Jan 5, 1981 Mon | | Boston | Winnipeg | Add Fight |
| Jan 8, 1981 Thu | | Detroit | Boston | (Rough) Labraaten-O'Connell |
| Jan 10, 1981 Sat | | Boston | NY Islanders | McCrimmon-Howatt |
| Jan 12, 1981 Mon | | Minnesota | Boston | Carlson-McCrimmon (5) Friest-Jonathan (4.5) Roberts-O'Reilly |
| Jan 13, 1981 Tue | | Boston | Detroit | Crowder-Hamel |
| Jan 15, 1981 Thu | | Boston | Chicago | O'Reilly-Kerr (5) McCrimmon-Higgins |
| Jan 17, 1981 Sat | | Philadelphia | Boston | Wilson-Crowder (4.7) Kerr-Milbury (7) |
| Jan 19, 1981 Mon | | Buffalo | Boston | McClanahan-Milbury (3) |
| Jan 22, 1981 Thu | | St. Louis | Boston | Scrum at 38:59 Stewart-Jonathan |
| Jan 24, 1981 Sat | | Los Angeles | Boston | Taylor-Bourque (7) |
| Jan 26, 1981 Mon | | Colorado | Boston | Cooper-Crowder (3.3) Hughes-O'Reilly (5.5) |
| Jan 29, 1981 Thu | | Winnipeg | Boston | Dudley-Bourque (6.2) Lukowich-Crowder (3) Dudley-O'Reilly (6.3) Geoffrion-Crowder (3) (Rough) Lecuyer-Park (6) Geoffrion-Kasper (5.5) |
| Feb 1, 1981 Sun | | NY Islanders | Boston | Langevin-O'Reilly Scrum at 60:00 |
| Feb 4, 1981 Wed | | Boston | Hartford | McCrimmon-Douglas (6) O'Reilly-Brubaker |
| Feb 5, 1981 Thu | | NY Rangers | Boston | Duguay-Milbury |
| Feb 7, 1981 Sat | | Boston | Montreal | (Cheap) Redmond-Lambert |
| Feb 8, 1981 Sun | | Quebec | Boston | Add Fight |
| Feb 12, 1981 Thu | | Boston | Colorado | Milbury-McEwen Milbury-Valiquette |
| Feb 14, 1981 Sat | | Boston | Los Angeles | Add Fight |
| Feb 18, 1981 Wed | | Boston | Vancouver | Crowder-McCarthy Line Brawl at 44:35 Kasper-Minor Park-Williams |
| Feb 20, 1981 Fri | | Boston | Edmonton | Crowder-Callighen Jonathan-Driscoll |
| Feb 21, 1981 Sat | | Boston | Calgary | Jonathan-Labraaten (Rough) Cashman-Plett O'Reilly-Peplinski |
| Feb 25, 1981 Wed | | Boston | Quebec | Add Fight |
| Feb 26, 1981 Thu | | Minnesota | Boston | Mini-Brawl at 0:07 Smith-Kasper (2.7) Payne-Crowder (2.7) Scrum at 2:53 Carlson-O'Reilly (2.5) Younghans-Milbury (4.5) Hartsburg-Gillis (3.3) Bench-Clearing Brawl at 8:58 (10) MacAdam-Bourque (5) Smith-McCrimmon (5.4) Roberts-McCrimmon (5.2) Smith-Crowder Maxwell-Cashman (7) Zanussi-Middleton (4.7) Shmyr-Kasper (5) (Rough) Young-Lalonde Christoff-Foster (3) Christoff-Lalonde (3) |
| Mar 1, 1981 Sun | | Buffalo | Boston | Add Fight |
| Mar 3, 1981 Tue | | Boston | St. Louis | Add Fight |
| Mar 4, 1981 Wed | | Boston | Minnesota | Jonathan-Zanussi (6.8) Milbury-Smith (3) Milbury-Carlson (2) |
| Mar 7, 1981 Sat | | Chicago | Boston | Add Fight |
| Mar 8, 1981 Sun | | Vancouver | Boston | Williams-Baron |
| Mar 11, 1981 Wed | | Boston | Toronto | (Cheap) unknown-Vaive Crowder-Boschman |
| Mar 13, 1981 Fri | | Boston | Washington | Add Fight |
| Mar 15, 1981 Sun | | Hartford | Boston | Add Fight |
| Mar 18, 1981 Wed | | Boston | NY Rangers | Add Fight |
| Mar 19, 1981 Thu | | Boston | Philadelphia | (Hit) O'Reilly-Wilson (3) O'Reilly-Wilson (7) O'Reilly-Wilson (8.2) Crowder-Murray |
| Mar 21, 1981 Sat | | Calgary | Boston | MacMillan-Jonathan (3.5) |
| Mar 23, 1981 Mon | | Edmonton | Boston | Add Fight |
| Mar 26, 1981 Thu | | Toronto | Boston | Add Fight |
| Mar 28, 1981 Sat | | Chicago | Boston | Kerr-Jonathan (3.8) Robidoux-Jonathan (2) |
| Mar 30, 1981 Mon | | Boston | Buffalo | Scrum at 42:08 (Rough) Vachon-Gare |
| Apr 2, 1981 Thu | | Washington | Boston | Walter-Milbury (6) |
| Apr 4, 1981 Sat | | Boston | Pittsburgh | Milbury-Price Crowder-Price |
| Apr 5, 1981 Sun | | Montreal | Boston | Nilan-Jonathan (3) Nilan-Jonathan (5.6) |
| Apr 8, 1981 Wed | Round 1 | Game 1 | Minnesota | Boston | Carlson-Milbury (5) |
| Apr 9, 1981 Thu | Round 1 | Game 2 | Minnesota | Boston | Maxwell-Jonathan (8.3) Carlson-Milbury (4.3) Carlson-Crowder (5.7) (Cheap) unknown-O'Reilly Smith-Park (6) |
| Apr 11, 1981 Sat | Round 1 | Game 3 | Boston | Minnesota | Crowder-Carlson (2) Jonathan-Ciccarelli (5) |